Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.
Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation.
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome.
Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.
Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.
Germline hypomorphic CARD11 mutations in severe atopic disease.
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Quantitative fragmentomics allow affinity mapping of interactomes.
PRKCB (PKC-beta) phosphorylates CARMA1
CARMA1 recruits MALT1 and BCL10 forming CBM Complex
Translocation of CARMA1 to Plasma membrane
Phosphorylation of CARMA1
Oligomerization of CARMA1
Auto-ubiquitination of TRAF6
Interaction of Bcl10 to CARMA1
Translocation of TRAF6 to CBM complex
Interaction and oligomerization of MALT1 to Bcl10
Activation of IKK complex
Activation of TAK1-TAB2 complex
Ubiquitination of NEMO by TRAF6
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
Phosphorylation of CARMA1 by PKC-theta
Recruitment of TRAF6 to CBM complex by binding to MALT1
Phosphorylation of IKK-beta by TAK1
Oligomerization of BCL10 and MALT1
Activation of TAK1 complex bound to pUb-TRAF6
Oligomerization of p-CARMA1
Auto-ubiquitination of TRAF6
Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency.
CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1.