Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Structure of the T4 baseplate and its function in triggering sheath contraction.
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Atomic structures of the T4 baseplate in pre- and post-attachment states define the interface of the gp11 homotrimer with gp10 and the gp12 short tail fiber and its rotation during the dome-to-star transition.
"Here we present the atomic structure of the approximately 6-megadalton bacteriophage T4 baseplate in its pre- and post-host attachment states and explain the events that lead to sheath contraction in atomic detail."
Deep research summary for Bacteriophage T4 gene 11 (gp11)
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gp11 is a trimeric structural baseplate adaptor that bridges gp10 and the gp12 short tail fibers to coordinate irreversible adsorption and contractile tail triggering.
"Enterobacteria phage T4 gene product 11 (gp11; UniProt P10929) is a **structural baseplate wedge/pin protein** that forms a **trimeric adaptor** at the baseplate periphery and serves as a key **mechanical and signaling interface** between the **baseplate (via gp10)** and the **short tail fibers (gp12)** required for irreversible adsorption and triggering of contractile tail function."
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gp11 associates with gp10 during wedge assembly and stabilizes the stowed gp12 short tail fibers in the dome-shaped baseplate.
"gp11 interacts with **gp10** during wedge initiation/assembly and associates functionally with **gp12 STFs**; gp11–gp12 association is part of stabilizing the dome-shaped baseplate."
UniProtKB record for P10929 (11_BPT4)
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gp11 is a baseplate wedge protein involved in tail assembly that connects the short tail fibers to the baseplate.
"Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:15315755). Involved in the tail assembly."
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gp11 forms a homotrimer (18 copies per baseplate) that interacts with both the gp10 trimer and the gp12 short tail fiber trimer.
"Homotrimer (PubMed:19896486, PubMed:27193680). The gp11 trimer interacts with gp10 trimer and with the short tail fiber (STF) composed of the gp12 trimer (PubMed:27193680)."
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gp11 is present in 18 copies per baseplate.
"Note=Present in 18 copies in the baseplate."