Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.
Executioner caspase-3 and caspase-7 are functionally distinct proteases.
Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation.
Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Toward an understanding of the protein interaction network of the human liver.
Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Palmitoylation of caspase-6 by HIP14 regulates its activation.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.
A reference map of the human binary protein interactome.
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
Caspase-mediated cleavage of Lamin A
Caspase-mediated cleavage of Lamin B1
Caspase-mediated cleavage of vimentin at TNLD (429)
TP53 stimulates CASP6 expression
Caspase-6 translocates to the nucleus
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.
Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.