nrdA (PA1156, Q9I4I1) notes

No deep-research provider was available. Literature: PMID:16829681 (abstract only).

Biology

Class Ia RNR R1 subunit PMID:16829681.
Duplicated ATP-cone, only the first functional PMID:16829681.
Complex PMID:16829681.
P. aeruginosa also has class II (nrdJab; genes/PSEAE/nrdJa) and class III RNRs.

Annotation decisions

GO:0004748 (IBA, IEA), GO:0005524 (IBA, IEA), GO:0005971 (IBA, IDA), GO:0009263 (IBA, IEA): ACCEPT.
GO:0000166 (IEA): TOO_GENERAL (ATP binding accepted). The earlier nrdJa review used MODIFY to ATP
binding for the same row; this batch follows the tier-2 is_a convention (TOO_GENERAL when an accepted
descendant is present).
Action counts: ACCEPT 8, TOO_GENERAL 1.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN000171388	GO:0005971 ribonucleoside-diphosphate reductase complex	9	186 (118 taxa)	GO:0005971, IDA, PMID:16829681 (PseudoCAP)	SOUND	Abstract states purified NrdA and NrdB form a tight alpha4beta4 complex.	E. coli NrdA P00452 and NrdE P39452, M. tuberculosis NrdE P9WH75, human RRM1 P23921, mouse Rrm1, yeast RNR1/RNR3, S. pombe cdc22, Dictyostelium rnrA	Yes; eight other class I R1 seeds, and the complex term suits the class I R1 clade

No PSEUDOCAP or GO_CENTRAL defect.