HSPA12B PN Consistency Notes

• Generated: 2026-06-18
• Project: PROTEOSTASIS
• Scope: priority-only PN rereview against local AIGR review and available deep-research artifacts
• UniProt: Q96MM6
• AIGR review status: COMPLETE
• Priority category: domain_exception
• Local AIGR project status: local_review_complete_not_phase1
• Related project: UNFOLDED_PROTEIN_BINDING.md

Source Files Checked

• AIGR review YAML: present - genes/human/HSPA12B/HSPA12B-ai-review.yaml
• AIGR review HTML: present - genes/human/HSPA12B/HSPA12B-ai-review.html
• Gene notes: present - genes/human/HSPA12B/HSPA12B-notes.md
• GOA TSV: present - genes/human/HSPA12B/HSPA12B-goa.tsv
• UniProt record: present - genes/human/HSPA12B/HSPA12B-uniprot.txt
• PROTEOSTASIS priority table: projects/PROTEOSTASIS/priority_genes.tsv
• PN projection report: projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv
• PN mapping audit: projects/PROTEOSTASIS/reports/pn_mapping_audit/current_mapping_scrutiny.tsv
• PN mapping file: none from current projection rows.

Deep Research Files

• genes/human/HSPA12B/HSPA12B-deep-research-falcon.md

AIGR Review Snapshot

• Description: HSPA12B is an endothelial-enriched, non-canonical HSP70-family protein with an atypical HSP70-like ATPase domain. The strongest experimental literature supports roles in endothelial cell migration, angiogenic sprouting, and maintenance of endothelial integrity during vascular stress. More recent work links HSPA12B to endothelial homeostasis during aging via XBP1-dependent ER-associated degradation of STING. Direct biochemical evidence for canonical HSP70 chaperone activity, unfolded-protein binding, or a core proteostasis function is lacking.
• Existing/core annotation action counts: MARK_AS_OVER_ANNOTATED: 4; NEW: 3

PN Consistency Summary

• Consistency: Priority-only record; no phase-1 dossier section exists yet. Local review status is local_review_complete_not_phase1. PN placement: Cytonuclear proteostasis > Chaperone > HSP70 system > HSP70. Main issue: MS1 inclusion is based on HSP70 architecture, but review supports endothelial and ERAD/STING context rather than canonical HSP70 folding activity
• PN story / NEW pressure: No current projected GO row; the value is exception/context tracking.
• Mapping strategy: Keep as an explicit exception to family/domain propagation. The PN family placement is informative, but the local review should decide whether canonical chaperone activity is actually supported.
• Verdict: Record as HSP70 GO:0140662 gene exception and sync the domain-only caveat to PN

Priority Review Context

• Category: domain_exception
• PN annotations: Cytonuclear proteostasis > Chaperone > HSP70 system > HSP70
• Why interesting: MS1 inclusion is based on HSP70 architecture, but review supports endothelial and ERAD/STING context rather than canonical HSP70 folding activity
• Suggested next step: Record as HSP70 GO:0140662 gene exception and sync the domain-only caveat to PN
• Related project: UNFOLDED_PROTEIN_BINDING.md

PN Projection Rows

• No current PN projected GO row for this gene. Treat this priority item as an exception, boundary, or context-tracking case rather than a direct GO propagation candidate.

PN Dossier Context

No phase-1 dossier exists for this priority-only gene. This note preserves the current PROTEOSTASIS boundary or exception decision and should be superseded by a dossier section if the gene is promoted into a full phase-1 batch.

Note

This file is generated from the current PROTEOSTASIS priority table, PN projection outputs, and local gene-review artifacts. Edit those source records rather than this generated note when correcting the underlying curation.