rde-8 (Q23342) review notes

Deep research: falcon timed out (exit 137) and perplexity-lite is unavailable. No
deep-research file was generated. The primary paper PMID:25635455 is cached with full text.

Key facts with provenance

• RDE-8 is a NYN-domain endoribonuclease PMID:25635455.
• Its D76N mutation is catalytic-dead. It is needed for RRF-1 RdRP activity in vitro
  PMID:25635455.
• It binds target mRNA only weakly or indirectly PMID:25635455.
• It is located in the cytoplasm and in Mutator foci PMID:25635455.
• Recruitment to Mutator foci requires MUT-15 and NYN-1/2 PMID:30036386.

Decisions

• RNA endonuclease (IBA, IDA) and siRNA processing: ACCEPT (core).
• mRNA binding (IBA, IDA): non-core.
• Nucleus IBA: over-annotated (no nuclear pool reported).
• 3'-UTR-mediated mRNA destabilization IBA: MODIFY to GO:0090625 siRNA-mediated gene
  silencing by mRNA destabilization.