ARRDC5 review notes

Sources

• Affinage: trust gates clear.
• All functional data are from mouse:
• PMID:37069147 (full text): knockout; male sterility; spermiogenesis defect.
• PMID:37997706 (abstract): SUN5/NDC1, SEC22A.
• PMID:41420860 (full text): TEX38; cytoplasmic droplet.
• PMID:40783453 (full text): TEX38/CLGN/PDILT; ADAM3.
• Mouse Arrdc5 (Q497K5) donor rows: IDA/EXP membrane and IMP spermatogenesis (QuickGO).
• The endosome and plasma membrane IBAs come from the ARRDC3-only node PTN008513893. ARRDC5 has no localization data for these compartments, and its biology is testis-specific, so they are non-core with an UNRESOLVED propagation review.

Decisions

• ACCEPT: membrane (IEA, ISS).
• MODIFY:
• Molecular adaptor activity (IBA) → protein-macromolecule adaptor activity.
• Spermatogenesis (ISS) → spermatid development.
• KEEP_AS_NON_CORE: cytoplasm (IBA); endosome and plasma membrane (IBA from ARRDC3).

2026-10-04 review round (PR #4211)

• ARRDC5 lacks PY motifs PMID:23236378. Location IBAs seeded only by ARRDC3 are UNDECIDED.
• Mouse Arrdc5 membrane (UniProt IDA PMID:37069147, EXP PMID:37997706): the full text of 37069147 has no ARRDC5 membrane statement, and 37997706 is abstract-only. UNDECIDED.
• ZDHHC19 S-palmitoylates ARRDC5 (PMID:40030029, not cached). This is ZDHHC19 activity, so there is no ARRDC5 annotation.