AGA notes

Deep research (just deep-research-falcon human AGA) timed out after 600 s ("All providers failed"),
so the literature work was done manually with PubMed and the cached publications/ files.

Function

• Lysosomal glycosylasparaginase (EC 3.5.1.26), Ntn-hydrolase: PMID:1281977.
• Disease mechanism: PMID:27906067
• Autoproteolytic activation: PMID:14616088; PMID:8776587. Activation cleavage occurs in the ER PMID:8776587.
• Finnish founder C163S abolishes activity and processing PMID:1904874.
• Core fucose must be removed by FUCA1 first (see FUCA1 notes, PMID:27491075).

Annotation notes

• Protein-binding rows from HuRI / neurodegeneration Y2H interactome removed as uninformative.
• IBA is_active_in cytoplasm (PTN000022481) marked over-annotated; node not inspected in detail.
• NEW: glycoprotein catabolic process (GO:0006516) and protein autoprocessing (GO:0016540).
• Module: modules/lysosomal_glycoprotein_degradation.yaml.