Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Liganded Gi-activating GPCR acts as a GEF for Gi
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
A novel endothelin receptor type-B-like gene enriched in the brain.
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.
The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.
CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.
Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1.
The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding.
Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain.
Neuroprotectin D1 and GPR37 protect against chemotherapy-induced peripheral neuropathy and the transition from acute to chronic pain.
Role and regulatory mechanism of GPR37 in neurological diseases.
A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons.
A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons.
The response to danger: Is it in your bones?
Spinal-level activation of GPR37 in TRPV1-expressing sensory neurons erases nociceptive system sensitization in murine models.
Distinct localization and potential functions of GPR37 signaling mediated by prosaposin and protectin D1 in the rat pituitary gland.