Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
Human VPS34 and p150 are Rab7 interacting partners.
Regulation of membrane traffic by phosphoinositide 3-kinases.
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Defining the membrane proteome of NK cells.
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
NRBF2 regulates macroautophagy as a component of Vps34 Complex I.
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex.
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.
PI3K-containing complexes phosphorylate PIP2 to PIP3
ULK1 phosphorylates AMBRA1:BECN1 complex
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
Rab5-mediated recruitment of class III PI3K to TLR9
Beclin-1 complex phosphorylates PtdIns
AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex
BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
ULK1 phosphorylates Beclin-1
Beclin-1 complex translocates to the ER
The phagophore extends from the PIP3-enriched structure
PIK3C3:PIK3R4 phosphorylates PI to PI3P
SARS-CoV-2 8:class I MHC binds BECN1
UniProtKB record for PIK3R4
Structural pathway for PI3-kinase regulation by VPS15 in autophagy.
A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi.
Manual primary full-text check of PMID:21062745
OpenScientist focused adjudication of PIK3C3 pexophagy and peroxisome localization (recovered cancelled-job artifact)
The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae.
Manual full-text check of Grunau et al. PMID:21121900
OpenScientist focused adjudication of PIK3R4 nucleus-vacuole-junction localization
Vps factors are required for efficient transcription elongation in budding yeast.
Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure.
The nucleus-vacuole junction at a glance.
Functional interaction between autophagy and ciliogenesis.
OpenScientist focused adjudication of PIK3R4 protein-phosphorylation complex contribution
-
The report identifies unresolved catalyst/subunit attribution for the historical complex assay; its categorical BP-removal lead exceeds that finding.
"Checked: abstract + seed description; unresolved."
-
The report claims a computational motif audit, but the delivered artifact set has no executed code or the named CSV; this is unverified computational provenance.
"Executed code + output; table saved as `vps15_catalytic_motif_audit.csv`."
Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy.
CryoEM provides detailed insights into how VPS15 regulates VPS34 activity.