Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
A reference map of the human binary protein interactome.
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits.
Deep research summary for KCTD12 (Falcon)
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KCTD12 is auxiliary subunit of GABA-B receptors binding GABAB2 CTD
"KCTD12 constitutively associates with the GABAB2 CTD and positions to rapidly engage Gbeta-gamma upon receptor activation"
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KCTD12 promotes receptor desensitization through Gbeta-gamma binding
"KCTD12 enhances desensitization kinetics, accelerates activation, and increases receptor surface levels"
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KCTD12 forms pentameric assemblies
"a pentameric KCTD12 complex binding the GBR is described"
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KCTD12 localizes to synaptic membranes
"In mouse cerebellum, KCTD12 localizes with mGlu1alpha in the same peri/post-synaptic nanodomains of Purkinje cell spines"
Cyberian deep research on KCTD12 function