Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Proteomics characterization of extracellular space components in the human aorta.
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners.
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DPT mentioned as a binding partner of mature LOX involved in ECM assembly
"Several LOX-PP partners such as fibrillar collagen I45, elastin10, fibronectin23, dermatopontin46,47, and fibromodulin48 bind to mature LOX, suggesting that both mature LOX and the propeptide are involved in ECM assembly and organization"
Role of dermatopontin in re-epithelialization - implications on keratinocyte migration and proliferation
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DPT is highly expressed in dermis and dermal fibroblasts, negligible in epidermis
"Dermatopontin (DPT), a non-collagenous matrix protein highly expressed in dermis is known for its striking ability to promote cell adhesion"
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DPT promotes keratinocyte migration and lamellipodia formation without affecting proliferation
"DPT also enhances the biological activity of transforming growth factor beta 1 which plays a central role in the process of wound healing"
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DPT enhances cell adhesion via integrin alpha3beta1
"Dermatopontin (DPT), a non-collagenous matrix protein highly expressed in dermis is known for its striking ability to promote cell adhesion"
Alterations of matrisome gene expression in naturally aged and photoaged human skin in vivo
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DPT promotes collagen and fibronectin fibrillogenesis
"The mRNA expression of the core matrisome, such as collagen 1A1 (COL1A1), decorin, and dermatopontin, is significantly reduced in aged skin compared to its young skin"
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DPT mRNA significantly reduced in aged and photoaged human skin
"The mRNA expression of the core matrisome, such as collagen 1A1 (COL1A1), decorin, and dermatopontin, is significantly reduced in aged skin compared to its young skin"
DNMT3A-dermatopontin axis suppresses breast cancer malignancy via inactivating YAP
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DPT is downregulated in breast cancer
"DNMT3a-mediated promoter hypermethylation lead to DPT downregulation"
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DPT directly binds YAP and increases YAP Ser127 phosphorylation
"DPT directly interacts with YAP and thus suppresses YAP translocating from cytoplasm to the nucleus"
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DPT restricts YAP nuclear localization and suppresses tumor growth
"DPT directly interacts with YAP and thus suppresses YAP translocating from cytoplasm to the nucleus"
Deep research on DPT function and annotations
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Dpt+ fibroblasts constitute >80% of skin fibroblasts
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Dpt+ fibroblasts are primary source of CSF1 sustaining dermal macrophages
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Depletion of Dpt+ fibroblasts causes loss of CD206hi CD64+ macrophages
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Loss of fibroblast-derived CSF1 delays wound healing
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DPT deficiency causes Ehlers-Danlos-like phenotypes in mice
Cyberian deep research on DPT function