LEU4 notes (YNL104C, P06208)

• Major alpha-isopropylmalate synthase, EC 2.3.3.13 [UniProt:P06208]; first committed step of the Leu branch.
• Two forms by alternative initiation PMID:3275644; short form functional and cytosolic PMID:3275644.
• Paralog specialisation PMID:25841022; heterodimers PMID:25841022
• Compartment logic PMID:25841022.
• Redundancy PMID:10790691

Curation observations

• YeastPathways RCA places the IPMS step in cytosol; true only for the minor short form. Kept non-core.
• Protein binding rows (Leu4-Leu9) -> MODIFY to GO:0046982 protein heterodimerization activity.
• Zinc ion binding (RCA, zinc proteome) kept non-core; physiological metal not established.