JAK3 notes

Deep research (falcon / perplexity-lite) failed (providers unavailable). Notes from cached publications and UniProt P52333.

• Binds C-terminal region of IL2RG (gamma c); JAK1 binds IL2RB PMID:7973658.
• Reconstitutes IL-2 signaling in JAK3-negative fibroblasts PMID:7973659.
• Activated by IL-2/IL-15 in T cells PMID:7568001, IL-7 in thymocytes and pre-B cells PMID:9182906, associates with IL4R in B cells PMID:7538655.
• Autophosphorylation Y904/Y939 positively regulates kinase activity PMID:18250158.
• TCPTP dephosphorylates JAK3 PMID:11909529.
• JAK3 deficiency -> SCID PMID:19290934; mouse KO loses gammadelta T and NK, reduced alphabeta PMID:9973401.
• GHR binding/GH signaling IBA from JAK family node; JAK3 is gamma c-specific -> marked over-annotated.

Localization: cytoplasmic, peripheral on cytoplasmic face of PM bound to gamma c; no extracellular exposure.