Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Shy1p occurs in a high molecular weight complex and is required for efficient assembly of cytochrome c oxidase in yeast.
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Shy1 is required for efficient complex IV assembly but residual normal enzyme can still form.
"Steady-state levels of the enzyme were found to be strongly reduced, the total amount of assembled complex being approximately 30% of control."
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.
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Shy1 likely acts downstream of the Cox14-Cox1-Mss51 regulatory complex.
"The release of Mss51p from the complex occurs at a downstream step in the assembly pathway, probably catalyzed by Shy1p."
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
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Shy1 is a complex IV assembly factor that interacts with Cox1 translational regulators and assembly intermediates.
"Shy1 interacts with Mss51 and Cox14, translational regulators of Cox1."
Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis.
Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
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The fission-yeast SURF1 homolog Shy1 is a mitochondrial complex IV assembly factor, corroborating conserved SURF1-family biology.
"Shy1 plays a pivotal role in the sustainability of the regular function of mitochondria by participating in the assembly of complex IV in S. pombe."
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S. pombe shy1 deletion only partly phenocopies loss of S. cerevisiae SHY1 or human SURF1, so the 2024 fission-yeast paper should be treated as ortholog corroboration rather than direct S. cerevisiae evidence.
"Unlike its homologs, deletion of shy1 does not critically disrupt respiratory chain assembly, indicating the presence of the compensatory mechanism(s) within S. pombe that ensure mitochondrial functionality."
SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration.
Falcon deep research report on SHY1