Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Liver-specific activities of FGF19 require Klotho beta.
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KLB is required for FGF19-FGFR4 binding, signaling, and downstream gene regulation.
"KLB is required for FGF19 binding to FGFR4, intracellular signaling, and downstream modulation of gene expression."
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Mouse FGF19 treatment represses hepatic CYP7A1.
"FGF19 injection triggers liver-specific induction of c-Fos and repression of CYP7A1."
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors.
FGF21 N- and C-termini play different roles in receptor interaction and activation.
Different roles of N- and C- termini in the functional activity of FGF21.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR4 phosphorylates PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR4
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
RAS GEFs promote RAS nucleotide exchange
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
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Human KLB is structurally a catalytically inactive glycoside-hydrolase-like protein.
"The first glutamate in D1 is replaced by N241, whereas the second glutamate in D2 is replaced by A889, indicating that neither GH domain in β-Klotho can function as an active glycoside-hydrolase enzyme."
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KLB is the high-affinity ligand-recognition component of the FGF21-FGFR1c signaling complex.
"In this model, β-Klotho functions as a primary high affinity receptor for FGF21, whereas FGFR1c functions as a catalytic subunit that mediates receptor dimerization and intracellular signaling."
Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
UniProtKB record for human KLB (Q86Z14)
Manual deep-research synthesis for human KLB
Manual KLB curation notes