Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

PMID:12761501

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

TRIM13/RFP2 was identified in a large-scale screen of human genes that activate NF-kappaB and MAPK signaling.

PMID:17314412

The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.

TRIM13/RFP2 is an ER membrane-anchored RING transmembrane E3 ubiquitin ligase that functions in ER-associated degradation (ERAD), undergoes RING-dependent autoubiquitination, and localizes to the perinuclear ER.

PMID:18248090

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

Screen of TRIM E3 ligases for antiretroviral activity; several TRIMs (including TRIM13) affect late stages (viral release) of the retroviral life cycle.

PMID:21333377

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.

TRIM13/RFP2 ubiquitinates and degrades MDM2 and AKT1, enhancing ionizing-radiation-induced p53 stabilization and apoptosis.

PMID:22178386

TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells.

TRIM13 positively regulates ER-stress-induced autophagy (coiled-coil-dependent), colocalizes with SQSTM1/p62 and ZFYVE1 at the perinuclear ER, and influences clonogenic ability (tumor-suppressor-like).

PMID:23077300

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

TRIM13 was among TRIMs that activate NF-kB/AP-1 signaling in a family-wide screen.

PMID:25152375

TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-κB activation.

In the presence of TNF, TRIM13 regulates IKBKG/NEMO ubiquitination and turnover to repress NF-kB activation, demonstrating a context-dependent negative role in NF-kB signaling.

Reactome:R-HSA-8867288

OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5

Reactome:R-HSA-901032

ER Quality Control Compartment (ERQC)