Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10438455

Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.

Chemical analysis identifies a beta1,4-linked reaction product.

"reaction product was formed via beta-1,4 linkage"

PMID:10473568

Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family.

Expressed human enzyme forms the Galbeta1-4Xyl linkage.

"the linkage formed was Galbeta1-4Xyl"

PMID:10506123

Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene.

Wild-type and A186D constructs show a Golgi staining pattern.

"the wild type or A186D clones showed Golgi pattern"

PMID:16583246

Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7).

R270C patient fibroblasts show reduced proliferation in the reported comparison.

"phenotypes and decreased proliferation rates."

PMID:20809901

Biochemical and thermodynamic characterization of mutated β1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome.

The R270C mutation impairs binding of the acceptor substrate.

"the R270C mutation strongly impaired the binding of the acceptor substrate."

PMID:24052259

Crystal structures of β-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding.

B4GALT7 transfers galactose from UDP-galactose to xylose on a proteoglycan acceptor.

"it transfers galactose from UDP-galactose to xylose on a proteoglycan acceptor substrate."

PMID:25416956

A proteome-scale map of the human interactome network.

The study reports a systematic map of human binary protein interactions.

"describe a systematic map of ?14,000 high-quality human binary protein-protein interactions."

PMID:32296183

A reference map of the human binary protein interactome.

HuRI interactions underwent repeated pairwise verification and sequence confirmation.

"pairwise verification by quadruplicate retesting and sequence confirmation."

PMID:34533190

A quantitative study of the Golgi retention of glycosyltransferases.

The study examines Golgi retention of glycosyltransferases quantitatively and systematically.

"study Golgi retention of glycosyltransferases quantitatively and systematically."

Reactome:R-HSA-1889981

B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker

Reactome:R-HSA-1971475

Glycosaminoglycan-protein linkage region biosynthesis

Reactome:R-HSA-3560804

Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker

file:human/B4GALT7/B4GALT7-uniprot.txt

UniProt Q9UBV7 B4GALT7 human record