Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.
Reconstitution of human telomerase activity in vitro.
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
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TERT forms distinct complex with RMRP RNA exhibiting RNA-dependent RNA polymerase activity
"Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner"
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Telomerase modulates Wnt signalling by association with target gene chromatin.
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TERT modulates Wnt signaling by interacting with BRG1 and beta-catenin at target gene promoters
"The telomerase protein component TERT (telomerase reverse transcriptase) interacts with BRG1 (also called SMARCA4), a SWI/SNF-related chromatin remodelling protein, and activates Wnt-dependent reporters in cultured cells and in vivo"
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Gene Ontology annotation based on curation of immunofluorescence data
Phylogenetic Assignment of Named Class from UniProt
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
Elongation Of The Telomeric Chromosome End
Deep research summary for TERT
Deep research summary for TERT (Cyberian)
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TERT contains four conserved domains - TEN, TRBD, RT, and CTE - that form a toroidal structure
"Human TERT contains four evolutionarily conserved structural domains that work together to accomplish the unique enzymatic function of telomere extension. These domains are arranged linearly from the N-terminus to C-terminus - the telomerase essential N-terminal (TEN) domain, the telomerase RNA-binding domain (TRBD), the reverse transcriptase (RT) domain, and the C-terminal extension (CTE) domain."
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Template translocation is a unique two-phase catalytic cycle distinguishing telomerase from conventional polymerases
"The first phase is the nucleotide addition phase, during which TERT synthesizes a single telomeric repeat by copying the template region of TERC onto the chromosome 3' end. The second phase is template translocation, which is unique to telomerase among polymerases."
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TPP1 TEL patch directly recruits telomerase to telomeres
"TPP1 interacts directly with TERT through a specific surface region called the TEL patch (TPP1 glutamate and leucine-rich patch) located within the N-terminal OB-fold domain of TPP1. The TEL patch contains four glutamic acid residues that confer a negative charge, which complements the highly basic TEN domain of TERT."
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TERT promoter mutations create de novo ETS binding sites in cancer
"Two hotspot point mutations in the TERT promoter (C228T and C250T), located 124 and 146 bp upstream of the translation start site, are found in over 50 cancer types with frequencies exceeding 80% in glioblastoma and melanoma. These mutations create an identical 11-nucleotide sequence that generates a de novo binding site for ETS family transcription factors."
Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Automatic Gene Ontology annotation based on Rhea mapping.
Functional requirement of p23 and Hsp90 in telomerase complexes.
Resistance to apoptosis in human cells conferred by telomerase function and telomere stability.
Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner.
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs.
Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.
Human telomerase contains two cooperating telomerase RNA molecules.
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.
Differential regulation of telomerase activity by six telomerase subunits.
Human Ku70/80 associates physically with telomerase through interaction with hTERT.
Functional conservation of the telomerase protein Est1p in humans.
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma.
Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro.
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain.
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase.
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.
GNL3L stabilizes the TRF1 complex and promotes mitotic transition.
PML-IV functions as a negative regulator of telomerase by interacting with TERT.
Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT.
HPV E6 protein interacts physically and functionally with the cellular telomerase complex.
Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.
High-throughput RNAi screening reveals novel regulators of telomerase.
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.
Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria.
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.
An enhanced H/ACA RNP assembly mechanism for human telomerase RNA.
Structure of active dimeric human telomerase.
HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene.
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles.
Involvement of telomerase reverse transcriptase in heterochromatin maintenance.
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7.
Telomerase reverse transcriptase regulates microRNAs.
Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.
Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.
Increased Stability of Nucleolar PinX1 in the Presence of TERT.
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.
Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity.
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
Extension of life-span by introduction of telomerase into normal human cells.
Recruitment of Telomerase RNP to the Telomeric Chromosome End
Alignment Of The RNA Template On The Telomeric Chromosome End
Disassociation of Telomerase RNP and the Chromosome End
Biogenesis and assembly of the telomerase RNP
Elongation of Extended Telomeric Chromosome End
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End
Beta-catenin recruits SMARCA4
MITF-M-dependent TERT expression
Understanding TERT Promoter Mutations - A Common Path to Immortality
TERT-Regulation and Roles in Cancer Formation
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
Structure of active human telomerase with telomere shelterin protein TPP1
Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
Structure of human telomerase holoenzyme with bound telomeric DNA
It all comes together at the ends - Telomerase structure, function, and biogenesis
Cell cycle-regulated trafficking of human telomerase to telomeres
Telomerase reverse transcriptase is required for the localization of telomerase RNA to Cajal bodies and telomeres in human cancer cells
Telomerase Mechanism of Telomere Synthesis