Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.
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Lamb et al. reconstituted Candida CYP51-mediated sterol 14alpha-demethylation using purified proteins and showed that a yeast microsomal cytochrome-b5/NADH-cytochrome-b5-reductase electron-transfer chain can support the reaction in vitro.
"fungal CYP51 mediated sterol 14alpha-demethylation"
Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments.
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Hahne et al. showed that S. cerevisiae MCR1 encodes mitochondrial NADH-cytochrome b5 reductase isoforms generated by incomplete translocation arrest at the mitochondrial outer membrane.
"The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of"
Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria.
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Haucke et al. mapped the N-terminal targeting determinants that direct S. cerevisiae Mcr1 to the mitochondrial outer membrane and intermembrane space.
"Mitochondrial NADH-cytochrome b5 reductase (Mcr1p) is encoded by a single"
UniProt record for Aspergillus nidulans mcr1
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The A. nidulans mcr1 Swiss-Prot record assigns Q5BG98 to EC 1.6.2.2, RHEA:46680, PTHR19370:SF171, and an inferred mitochondrial outer-membrane localization.
"PANTHER; PTHR19370:SF171; NADH-CYTOCHROME B5 REDUCTASE 2"
PTHR19370 PAINT annotations
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PAINT node PTN000452207 propagates cytochrome-b5 reductase activity and mitochondrial localization to A. nidulans mcr1, while PTN000452208 propagates an ergosterol-biosynthesis process assertion from S. cerevisiae MCR1.
"PTHR19370 PTN000452207 GO:0004128 F IBD false"