ALKBH3 is a well-characterized AlkB-family dioxygenase that reverses m1A and m3C in single-stranded DNA and RNA.
- Activity: PMID:12486230
- Partner complex: it works with the ASCC complex PMID:22055184
- mRNA m1A eraser: PMID:26863410
Decisions:
- Accepted: all MF, DNA-repair, nucleus and cytoplasm rows.
- Kept as non-core: proliferation (IMP, cell-type specific).
- Negative regulation of cytoplasmic translation: MARK_AS_OVER_ANNOTATED (changed in round 1 of PR #3977). ALKBH3 was never perturbed with translation as the readout; the link is a correlation.
- No in_complex for the ASCC complex: GO has no CC term for it (OLS search, 2026-10-04).
- ASCC3 interaction row: MODIFY to GO:0044877 protein-containing complex binding, since ALKBH3 co-purifies with the whole ASCC complex.
- Nine yeast two-hybrid protein-binding rows (GLRX3, GOLGA2, IKZF1, LNX1, AK8): REMOVE.