Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.
The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA.
Expression of DNA methyltransferase (Dnmt1) in testicular germ cells during development of mouse embryo.
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells.
Replication-independent chromatin loading of Dnmt1 during G2 and M phases.
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages.
A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA.
Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation.
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.
DNMT1 interacts with the developmental transcriptional repressor HESX1.
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA.
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice.
Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.
Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1.
Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).
lincRNAs act in the circuitry controlling pluripotency and differentiation.
Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice.
Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation.
Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages.
Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.
Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.
LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration.
DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination.
Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth.
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance.
The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells.
Uhrf1:Chromatin binds Dnmt1
Dnmt1 methylates cytosine in hemimethylated DNA
Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene
NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene
NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes
Falcon deep research for mouse Dnmt1 (DNA (cytosine-5)-methyltransferase 1)
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Falcon deep research confirms the core function of mouse Dnmt1 (UniProt P13864)
as the replication-coupled maintenance DNA (cytosine-5)-methyltransferase that
transfers a methyl group from S-adenosylmethionine to the C5 position of cytosine
in CpG DNA, with a strong intrinsic preference for hemimethylated over unmethylated
CpG substrates.
"DNMT1 catalyzes transfer of a methyl group to the **C5 position of cytosine** in CpG DNA."
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In vivo maintenance methylation depends on UHRF1-mediated ubiquitin signaling:
UHRF1 recognizes hemimethylated CpG, ubiquitylates histone H3 (K18/K23) and PAF15,
and these mono-ubiquitin marks bind the DNMT1 RFTS domain to relieve RFTS-mediated
autoinhibition. PCNA interaction contributes to replication-site targeting but its
disruption causes only modest impairment, implying redundant recruitment routes.
"mono-ubiquitin** marks on **histone H3 (notably H3K18 and H3K23)** and on **PAF15** (a PCNA-associated factor)"
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Falcon situates the numerous transcriptional-silencing, heterochromatin, imprinting
and developmental phenotypes (e.g. cleft palate on early cranial-neural-crest Dnmt1
deletion; SHH-medulloblastoma dependency) as downstream consequences of the maintenance
methyltransferase activity rather than independent core molecular functions.
"DNMT1-dependent maintenance methylation is required to sustain proliferation and differentiation programs in a narrow developmental window"