GCV1 notes (YDR019C, P48015)

• Glycine cleavage T-protein (aminomethyltransferase, EC 2.1.2.10) PMID:9047339; disruption abolishes GCS PMID:9047339.
• GDC = P/H/T/L (Gcv2/Gcv3/Gcv1/Lpd1) PMID:8830251. Mitochondrial [UniProt:P48015; PMID:14576278 proteomics].
• Regulated by cytoplasmic CH2-THF PMID:10871621.

Curation observations

• YeastPathways RCA cytosol (GLYCLEAV-PWY) is a default-compartment artefact -> REMOVE.

2026-11-04 audit to COMPLETE

• Provider deep research was not generated in this session (no API keys); cached abstracts and the SGD description only.
• Added reasons to every row and completed truncated quotes (all cached papers are abstract-only).
• GO:0006546 glycine catabolic process (IEA, IMP, NAS) -> MODIFY to GO:0019464 glycine decarboxylation via glycine
  cleavage system (is_a descendant, already on the gene by IBA/RCA).
• GO:0005829 cytosol RCA (GO_REF:0000123) REMOVE kept; WRONG_TERM source defect for SGD (should be mitochondrion).
• Mitochondrion rows kept at the root organelle; only one line (predicted transit peptide) for the matrix, so no
  sub-compartment NEW row.
• Summaries quoted by interpro/panther/PTHR43757/PTHR43757-review.yaml left unchanged.

2026-11-10 glycine cleavage module completion pass (Claude, AI-assisted)

• Every row now carries a verbatim supporting quote; truncated UniProt quotes were completed to the end of the claim.
• Broad parent rows shared across the module's P/H/T/L reviews were harmonized: glycine metabolic/catabolic process (and amino acid metabolic process) -> MODIFY to GO:0019464; for the L proteins 2-oxoglutarate metabolic process and tricarboxylic acid cycle -> MODIFY to GO:0120551, generic oxidoreductase parents -> MODIFY to GO:0004148, FAD binding ACCEPT.