cueR (PA4778, Q9HV30) review notes

No deep-research provider was available; notes below come from the UniProt
record, the cached publication and PubMed (full text of PMID:20233934 was not
returned by the PubMed MCP, so abstract only).

Function

MerR-family Cu(+)-sensing regulator; LasR activates cueR, and CueR directly binds
and activates five promoters PMID:20233934.
Disruption increases copper sensitivity PMID:20233934.
UniProt (curated, PubMed:31790504): also represses H2-T6SS, azu and oprC under
copper-rich conditions; metallated by CopZ1/CopZ2 (PubMed:30718281).

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN001575588	GO:0006355 regulation of DNA-templated transcription	9	114 (31 taxa)	GO:0045893 positive regulation of DNA-templated transcription, IMP, PMID:20233934 (PseudoCAP)	SOUND	The abstract states direct promoter binding and activation by PA4778 itself, plus disruption phenotypes; the row is about CueR's own regulatory activity, not a downstream phenotype. The node term is the generic MerR-family process, right for a clade of activators and repressors.	E. coli CueR P0A9G4, ZntR P0ACS5, BluR P75989; Xanthomonas SoxR Q8P6Y4; M. tuberculosis HspR O06302; B. subtilis TnrA Q45666; S. coelicolor HspR P40183; PAO1 BrlR Q9HUT5	Yes; E. coli CueR and ZntR alone carry strong experimental support. No GO_CENTRAL defect. Shared with brlR (see brlR notes; same verdict, no defect).
PTN001249777	GO:0045893 positive regulation of DNA-templated transcription	3	26 (13 taxa)	same row	SOUND	As above. The CueR/ZntR metal-sensor clade are classical MerR activators, so the positive-regulation node term suits the clade.	E. coli CueR P0A9G4, ZntR P0ACS5	Yes. No GO_CENTRAL defect.

PseudoCAP defects from this gene: none.