Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Eps1, a novel PDI-related protein involved in ER quality control in yeast.
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Eps1 is an ER-localized PDI-family membrane protein needed to retain and degrade Pma1-D378N.
"Because Eps1 is required for retention and degradation of Pma1-D378N, we propose a model in which Eps1 acts as a novel membrane-bound chaperone in ER quality control."
Functional differences in yeast protein disulfide isomerases.
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EPS1 is one of the nonessential yeast PDI1 homologs.
"The Saccharomyces cerevisiae genome, however, contains four other nonessential genes with homology to PDI1: MPD1, MPD2, EUG1, and EPS1."
Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family.
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Eps1 is an ERAD recognition component for Pma1-D378N.
"Genetic interactions with other mutants of the ERAD machinery and induction of the unfolded protein response in eps1Delta cells support a general role for Eps1 as a recognition component of the ERAD pathway."
Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.
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Eps1 interacts with multiple ER PDI/chaperone proteins and has chaperone activity in this assay context.
"Eps1p interacts with Pdi1p, Eug1p, Mpd1p, and Kar2p with dissociation constants (KD) in the range of 10(-7) to 10(-6)."
Falcon deep research report on EPS1