Annotation inferences using phylogenetic trees
Gene Ontology annotation of UniProtKB entries based on the manual curation of subcellular locations
Gene Ontology annotation based on curation of immunofluorescence data
Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9.
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HSPB9 is a small heat shock protein specifically expressed in testis, in spermatogenic cells from late pachytene spermatocyte to elongate spermatid stages; it is rapidly evolving (mouse-human ~38% divergence), suggesting a sex-related role.
Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1.
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HSPB9 is a cancer/testis antigen and interacts with TCTEL1 (DYNLT1), a dynein light chain, in yeast two-hybrid and co-immunoprecipitation, with co-expression in testis.
HSPB7 is a SC35 speckle resident small heat shock protein.
UniProt entry Q9BQS6 (HSPB9_HUMAN), Heat shock protein beta-9
Falcon deep research report for HSPB9
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HSPB9 carries the conserved alpha-crystallin/HSP20 domain characteristic of the ATP-independent small heat shock protein chaperone family, but is among the least characterized HSPBs and has no experimentally validated chaperone (holdase) activity or substrate repertoire beyond the DYNLT1/TCTEL1 interaction.
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HSPB9 lacks a canonical nuclear localization signal, so its observed nuclear localization may depend on interaction with binding partners; the TCTEL1/DYNLT1 interaction is reported to occur via the HSPB9 C-terminus.