Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Rab7b controls trafficking from endosomes to the TGN.
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RAB7B is essential for retrograde transport from endosomes to TGN
"Rab7b is required for normal lysosome function, and, in particular, that it is an essential factor for retrograde transport from endosomes to the trans-Golgi network (TGN)"
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Wild-type RAB7B is lysosome-associated, GTP-bound form localizes to Golgi
"wild-type Rab7b is lysosome associated whereas an activated, GTP-bound form of Rab7b localizes to the Golgi apparatus"
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RAB7B dominant-negative mutant impairs lysosomal function
"Expression of Rab7b T22N, a Rab7b dominant-negative mutant, impairs cathepsin-D maturation and causes increased secretion of hexosaminidase"
Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association.
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RAB7B promotes megakaryocytic differentiation through IL-6/STAT3
"Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association"
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RAB7B is a late endosome/lysosome-localized myeloid small GTPase
"Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation"
Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
A reference map of the human binary protein interactome.
TBC1D15 accelerates GTP hydrolysis by RAB7
A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration.
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RAB7B directly binds myosin II
"Rab7b, a Rab that controls the transport between late endosomes and the trans Golgi network, interacts directly with myosin II. We illustrate the functional relevance of this interaction, demonstrating that myosin II mediates the transport of Rab7b endosomes, as Rab7b dynamics are strongly affected after myosin II depletion or inhibition."
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RAB7B regulates cell migration through RhoA and myosin light chain phosphorylation
"We also demonstrate that a member of the Rab family regulates actin remodeling and, consequently, influences cell adhesion, polarization and migration. We find the molecular mechanism by which Rab7b influences stress fiber formation - through controlling the activation status of the small GTPase RhoA and therefore influencing myosin light chain phosphorylation."
Deep research review of RAB7B function
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RAB7B directly binds myosin II as effector/motor
"Rab7b binds myosin II (validated by Y2H, co-IP of endogenous proteins in human MDDCs, and recombinant pull-downs)"
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TBC1D5 is a GAP for RAB7B
"TBC1D5 is a GAP for Rab7b whose activity is augmented by retromer"
Cyberian deep research on RAB7B function