Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates.
Domina (Dom), a new Drosophila member of the FKH/WH gene family, affects morphogenesis and is a suppressor of position-effect variegation.
Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila.
Genes required for mitotic spindle assembly in Drosophila S2 cells.
The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster.
Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors.
Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway.
The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.
Jumu is required for the activation of JAK/STAT in Drosophila lymph gland development and epidermal wounds.
Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division.
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Jumu regulates a network of cardiac progenitor cell-division genes; perturbation studies establish downstream function but do not prove direct binding at every target.
"Phenotypic analysis of a subset of these targets identified 21 jumu-regulated genes that mediate cardiac progenitor cell division"
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Which jumu-activated genes are direct targets has not yet been tested.
"we intend to assess which of these genes are direct targets of Jumu in the future"
PANTHER 19.0 subfamily placement of jumu and FOXN proteins (re-review analysis)
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Jumu is classified with vertebrate FOXN4 orthologs in PANTHER 19.0 subfamily PTHR13962:SF17, not in PTHR46721:SF3 as the UniProt cross-reference states.
"In the official PANTHER 19.0 classification, jumu Q9XTP7 sits in PTHR13962:SF17"
Falcon deep research report on jumu
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Jumu-regulated cardiac division effectors such as neb are genetically validated, but direct enhancer binding has not been shown.
"Direct functional binding of Jumu to a *neb* enhancer was not demonstrated in that study."
Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.
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In an embryonic RNAi screen, jumu knockdown increased the number of peripheral sensory neurons and caused dendrite morphogenesis defects.
"RNAi of six other genes, including jumeau , a winged-helix TF known to regulate neuroblast cell fate and the number of PNS neurons, similarly caused an increase in neuronal number as well as defects in dendrite morphogenesis."
FlyBase gene description for jumu (DROME)