Krtap3-2 (mouse) review notes

Family-batched review of mammalian keratin-associated proteins (KRTAPs). No deep-research report was generated for this gene; evidence comes from UniProt, cached PubMed records and family reviews.

Family-level evidence

• KAPs form the matrix cross-linking hair keratin IFs PMID:16382671
• PMID:22298953
• Mammal-specific family PMID:18721477
• HGT function less clear PMID:23791804

Gene-specific notes

• Mouse Krtap3-2 (PE 3, inferred from homology) has no gene-specific functional literature; UniProt cites only genome/cDNA sequencing (PMID:15489334, PMID:16141072, PMID:19468303). Assessment rests on the KAP3 family: ovine KAP3-1 (BIIIB2) was sequenced directly from wool high-sulfur protein PMID:27240405.

Curation decisions

• MF: GO:0030281 structural constituent of cutaneous appendage (OLS-verified; child of GO:0005198). ND root and IEA structural molecule activity rows refined to it.
• CC: GO:0045095 keratin filament (ACCEPT/NEW/MODIFY of ND root).
• BP: GO:0031424 keratinization; hair cycle/follicle development not used (KAPs are downstream structural products).
• ARBA cytosol: KEEP_AS_NON_CORE, harmonized with the human KRTAP reviews (KAPs are synthesized in the cytoplasm of the keratinizing cell but act in the keratin matrix; true but not the site of function).
• ISO identical protein binding (HuRI Y2H donors): MARK_AS_OVER_ANNOTATED.
• No bare GO:0005515 rows in this gene's GOA.