GO_REF:0000015

Use of the ND evidence code for Gene Ontology (GO) terms

Standard GO reference for No Data annotations when no experimental evidence exists for a particular aspect of gene function.

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Standard GO reference for IEA annotations based on UniProt keyword mapping. For irg-1, keywords KW-0391 (Immunity) and KW-0399 (Innate immunity) were mapped to corresponding GO terms.

PMID:16968778

A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.

Genome-wide transcriptomic study identifying genes induced during P. aeruginosa infection in C. elegans intestine

"Through an unbiased genome-wide study performed in Caenorhabditis elegans, we identified a conserved function for endodermal GATA transcription factors in regulating local epithelial innate immune responses."
Identified ELT-2 as major regulator of intestinal innate immune responses

"Gene expression and functional RNAi-based analyses identified the tissue-specific GATA transcription factor ELT-2 as a major regulator of an early intestinal protective response to infection with the human bacterial pathogen Pseudomonas aeruginosa."

PMID:20133860

bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.

First paper to characterize irg-1 as a specific infection response gene

"We generated a GFP reporter for one of these genes, infection response gene 1 (irg-1), which is induced strongly by wild-type P. aeruginosa strain PA14"
irg-1 is strongly induced by virulent P. aeruginosa PA14 but not by attenuated strains or other pathogens

"infection response gene 1 (irg-1), which is induced strongly by wild-type P. aeruginosa strain PA14, but not by other C. elegans pathogens or by other wild-type P. aeruginosa strains that are weakly pathogenic to C. elegans"
zip-2 bZIP transcription factor is required for irg-1 induction

"This screen identified zip-2, a bZIP transcription factor that is required for inducing irg-1, as well as several other genes, and is important for defense against infection by P. aeruginosa."
irg-1 induction is independent of pmk-1, dbl-1, kgb-1, and bar-1 pathways

"Most of these genes are induced independently of known immunity pathways."
zip-2 is important for defense against P. aeruginosa

"These data indicate that zip-2 is part of a specialized pathogen response pathway that is induced by virulent strains of P. aeruginosa and provides defense against this pathogen."

file:worm/irg-1/irg-1-deep-research-falcon.md

Deep research report on irg-1