Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.
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F32H2.5 is the only predicted full-length FAS gene; RNAi of F32H2.5/F32H2.6 causes lethal growth arrest without selective change in FA composition.
"There is one predicted FAS gene, F32H2.5, and its shorter homolog, F32H2.6, in the C. elegans genome."
The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis.
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Positional cloning of fr8 (M241I) identified fasn-1 as human FASN ortholog; transgenic fasn-1 increases C16:0 and C18:0.
"the rescued siblings did show significantly increased levels of C16:0 (palmitic acid), the main product of FASN-1, and its elongated form C18:0"
A potential role for fatty acid biosynthesis genes during molting and cuticle formation in Caenorhabditis elegans.
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fasn-1 RNAi reduces triglyceride production and causes molting and cuticle defects.
"knockdown of the proteins encoded by these genes using RNA interference produced severe defects in triglyceride production, molting, and reproduction"
The fasn-1(g14ts) allele is a Gly1830Arg missense mutation in C. elegans FASN-1.
De novo lipid synthesis and polarized prenylation drive cell invasion through basement membrane.
Loss of ptr-6 restores eggshell integrity and embryonic viability in Caenorhabditis elegans fatty acid synthase mutants.
The fatty acid synthase gene is a conserved p53 family target from worm to human.
PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans.
Physiological roles for mafr-1 in reproduction and lipid homeostasis.
Reductive death is averted by an ancient metabolic switch.
UniProt entry P91871 (fasn-1, C. elegans)
FASN-1 catalytic-residue conservation versus human FASN
fasn-1 manual literature synthesis