Falcon deep research report for HSPA8
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein.
Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70.
A molecular chaperone complex at the lysosomal membrane is required for protein translocation.
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.
AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.
Abi1 is essential for the formation and activation of a WAVE2 signalling complex.
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.
HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
A human protein-protein interaction network: a resource for annotating the proteome.
Towards a proteome-scale map of the human protein-protein interaction network.
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays.
CHIP interacts with heat shock factor 1 during heat stress.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate.
Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle.
HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain.
Molecular composition of IMP1 ribonucleoprotein granules.
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
Identification of potential protein interactors of Lrrk2.
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells.
The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.
Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex.
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
Defining the membrane proteome of NK cells.
Chaperone-mediated autophagy: molecular mechanisms and physiological relevance.
Molecular architecture of the human Prp19/CDC5L complex.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates.
The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.
A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.
The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.
Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages.
Protein profile of exosomes from trabecular meshwork cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1.
Dynamic protein-protein interaction wiring of the human spliceosome.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.
Interplay of LRRK2 with chaperone-mediated autophagy.
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Splicing and beyond: the many faces of the Prp19 complex.
Histone deacetylase 10 promotes autophagy-mediated cell survival.
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
The co-chaperone DNAJC12 binds to Hsc70 and is upregulated by endoplasmic reticulum stress.
Identification and comparative analysis of hepatitis C virus-host cell protein interactions.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish.
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
RING finger protein RNF207, a novel regulator of cardiac excitation.
A proteome-scale map of the human interactome network.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide.
Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s.
Widespread macromolecular interaction perturbations in human genetic disorders.
Quantitative interaction proteomics of neurodegenerative disease proteins.
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
Salivary protein histatin 3 regulates cell proliferation by enhancing p27(Kip1) and heat shock cognate protein 70 ubiquitination.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
An inter-species protein-protein interaction network across vast evolutionary distance.
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.
A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins.
Architecture of the human interactome defines protein communities and disease networks.
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy.
ABHD8 antagonizes inflammation by facilitating chaperone-mediated autophagy-mediated degradation of NLRP3.
Multimodal cell maps as a foundation for structural and functional genomics.
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
Role of auxilin in uncoating clathrin-coated vesicles.
Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11.
BAG-1 modulates the chaperone activity of Hsp70/Hsc70.
Molecular chaperones as HSF1-specific transcriptional repressors.
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
HSF1 acetylation at Lys80
HSP70 binds to HSP40:nascent protein
trans-Golgi Network Derived Vesicle Uncoating
trans-Golgi Network Derived Lysosomal Vesicle Uncoating
AUF1 binds translation and heat shock proteins
AUF1 (hnRNP D0) is ubiquitinylated
HSF1-mediated gene expression
Acetylated HSF1 dissociates from DNA
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein
ATP binding to HSP90 triggers conformation change
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
Expression of HSPA8, ALOX15
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Release of GABA at the synapse
METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8
GABA loaded synaptic vesicle Docking and Priming
Formation of the Spliceosomal B* complex
Formation of the Spliceosomal C* complex
Formation of the Spliceosomal Bact complex
Formation of the Spliceosomal P complex and exon ligation
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)
Disassembly of the Intron Lariat Spliceosome (new)
Formation of the Spliceosomal C complex containing intron lariat
FA core complex:HSP70s binds PKR