Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
-
IRE-1 mediates xbp-1 mRNA splicing for UPR transcriptional activation
"C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress"
-
ire-1 and pek-1 act in complementary pathways essential for development
"ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival"
-
C. elegans requires ire-1 for survival upon ER stress
"C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress"
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
-
IRE1-dependent splicing of xbp-1 mRNA conserved in C. elegans and mammals
"Activation of the UPR causes IRE1-dependent splicing of a small intron from the XBP-1 mRNA both in C. elegans and mice"
-
Mutations in ire-1 or xbp-1 abolish UPR in C. elegans
"mutations in either ire-1 or the transcription-factor-encoding xbp-1 gene abolished the UPR in Caenorhabditis elegans"
-
IRE1 directly cleaves XBP-1 mRNA
"Purified mouse IRE1 accurately cleaved XBP-1 mRNA in vitro, indicating that XBP-1 mRNA is a direct target of IRE1 endonucleolytic activity"
APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.
-
ire-1 required for transcriptional upregulation of apy-1 upon ER stress
"ER stress induced by tunicamycin or high temperature resulted in increased transcription of apy-1. This increase was not observed in C. elegans mutants defective in ire-1 or atf-6"
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.
-
IRE-1 required for hypoxic preconditioning
"the pharmacological induction of misfolded proteins is itself sufficient to stimulate a delayed protective response to hypoxic injury that requires the UPR pathway proteins IRE-1, XBP-1, and ATF-6"
Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity.
-
XBP-1 deficiency causes constitutive ER stress with elevated IRE-1 activity
"XBP-1 deficiency results in constitutive ER stress, reflected by increased basal levels of IRE-1 and PEK-1 activity under physiological conditions"
A novel interaction between aging and ER overload in a protein conformational dementia.
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity.
-
Neuronal XBP-1s activates UPR in distal cells non-autonomously
"Neuronally derived XBP-1s was sufficient to rescue stress resistance, increase longevity, and activate the UPR(ER) in distal, non-neuronal cell types through a cell-nonautonomous mechanism"
It's all in your mind: determining germ cell fate by neuronal IRE-1 in C. elegans.
-
IRE-1 mediates ER stress-induced germline apoptosis independently of XBP-1
"This process is mediated by the ER stress response sensor IRE-1, but is independent of its canonical downstream target XBP-1"
-
Neuronal (ASI) IRE-1 activation sufficient to induce germline apoptosis
"activation of ire-1, specifically in the ASI neurons, but not in germ cells, is sufficient to induce apoptosis in the germline"
Deep research report on C. elegans ire-1 gene function
-
IRE-1 executes RIDD of daf-7 mRNA in ASI neurons
"In C. elegans, recent work identifies daf-7 (a TGFbeta family ligand expressed in ASI neurons) as a physiological RIDD substrate"
Deep research report on ire-1