Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet.
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome.
Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation.
Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2.
Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking.
Defining the membrane proteome of NK cells.
Human delta opioid receptor biogenesis is regulated via interactions with SERCA2b and calnexin.
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice.
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.
Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages.
The unfolded protein response: integrating stress signals through the stress sensor IRE1α.
Global landscape of HIV-human protein complexes.
Palmitoylated calnexin is a key component of the ribosome-translocon complex.
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Calnexin is a major ER glycoprotein-folding chaperone whose palmitoylation by DHHC6 couples it to the ribosome-translocon complex for co-translational client capture.
"calnexin, a major ER chaperone involved in glycoprotein folding"
Palmitoylated calnexin is a key component of the ribosome-translocon complex.
Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation.
Autophagosomes form at ER-mitochondria contact sites.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E.
SERPINA2 is a novel gene with a divergent function from SERPINA1.
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor.
Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum.
TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis.
HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.
Architecture of the human interactome defines protein communities and disease networks.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.
A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss.
Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.
TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities.
NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly.
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NACHO-mediated alpha7 nicotinic receptor assembly requires N-glycosylation and calnexin chaperone activity.
"NACHO-mediated effects on α7 assembly and channel function require N-glycosylation and calnexin chaperone activity."
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Multimodal cell maps as a foundation for structural and functional genomics.
The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin.
Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5.
Interaction of invariant chain trimer and MHC II alpha beta dimer
Formation of nonameric complex
Binding of calnexin/calreticulin to the unfolded protein
Removal of the third glucose by glucosidase II and release from the chaperone
CANX dissociates from IL27:EBI3
CANX dissociates from IL12A:EBI3
Dissociation of CANX from nonameric complex
Maturation of spike protein
Trimmed spike protein binds to calnexin
Binding of newly synthesized MHC class I heavy chain (HC) with calnexin
Interaction of beta-2-microglobulin (B2M) chain with class I HC
Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1
CANX binds Glu1Man9GlcNAc2-CDH1
CANX UniProtKB record (P27824)
Manual CANX curation notes