Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).
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RAIG-3/GPRC5C is a retinoic acid-inducible type 3 GPCR with a short N-terminus, expressed at the cell surface.
"in contrast to other type 3 GPCRs, RAIG-1, RAIG-2, and RAIG-3 have only short N-terminal domains"
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.
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Hyaluronic acid preserves HSC dormancy through GPRC5C.
"we show that hyaluronic acid, a bone marrow extracellular matrix component, preserves dormancy through GPRC5C"
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells.
Identifying the localization and exploring a functional role for Gprc5c in the kidney.
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Gprc5c is on the apical membrane of proximal tubule and regulates NHE3 and acid-base balance.
"Gprc5c localized to the apical membrane of renal proximal tubules (PTs) in mice, rats, and humans."
GPRC5C regulates the composition of cilia in the olfactory system.
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GPRC5C localizes to the ciliary transition zone of olfactory sensory neurons.
"In closer examination, GPRC5C was found in the ciliary transition zone."
The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response.
Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction.
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GPRC5C dimerizes with AT1 and facilitates angiotensin II binding and vascular contraction.
"Our data show that GPRC5C regulates Ang II-dependent vascular contraction by facilitating AT1 receptor-ligand binding and signaling."
Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice.
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GPRC5C shares the GPRC5B dimerization interface; blocking it alters EP2/AT1 signalling.
"Taken together, GPRC5C and GPRC5B share a partially conserved dimerization interface that can be blocked by decoy peptides to induce macrophage hyperactivity and improve host defense in the fecal peritonitis model."
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis.
G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals.
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GPRC5C depletion reduces osteoblast mineralization.
"Loss of function analyses revealed that shRNA-mediated depletion of GPRC5C decreases expression of bone markers (e.g., BGLAP and IBSP) and mineral deposition in response to BMP2 or GSK126."
Molecular evolution of a chordate specific family of G protein-coupled receptors.
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GPRC5 receptors are chordate-specific; insect BOSS is only distantly related and has a long N-terminus.
"Together our results suggest that GPRC5 receptors seem to be a chordate specific class of GPCRs."
Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons.
Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS.
Fast co-evolution of sevenless and bride of sevenless in endopterygote insects.
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The BOSS extracellular region co-evolves with Sevenless and is not conserved outside Diptera.
"The extracellular region, however, is only detectably conserved within but not outside Diptera."
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.
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The mammalian ROS1 ligand is the secreted protein NELL2.
"neural epidermal growth factor-like-like 2 (NELL2), specifically binds to an orphan receptor tyrosine kinase, c-ros oncogene 1 (ROS1)"
IPR002956 / InterPro2GO check for mouse Gprc5c (Q8K3J9)
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IPR002956 matches only Drosophila BOSS and mouse Gprc5c among Swiss-Prot entries, on TM1/TM6 segments; human GPRC5C does not match.
"Q9NQ84 human GPRC5C: IPR002956 match = no"