Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death.
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FBX33/FBXO33, the mouse homolog of human F-box protein 33, is a component of an SCF E3 ubiquitin ligase that targets the multifunctional regulator YB-1 (YBX1)/dbpB/p50 for polyubiquitination and proteasomal degradation; unlike typical F-box proteins it lacks C-terminal LRR/WD40 domains and associates with YB-1 via its N-terminus.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A High-Density Map for Navigating the Human Polycomb Complexome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability.
Falcon deep research report for human FBXO33
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FBXO33 is an F-box substrate adaptor of a CUL1-based CRL/SCF-like ubiquitin ligase that selects specific protein substrates for ubiquitination and proteasomal degradation, with documented substrates including YBX1, expanded-polyQ ATXN3, p53 and MYC.
"it is an **F-box substrate adaptor of a CUL1-based CRL/SCF-like ubiquitin ligase**, functioning primarily to **select specific protein substrates (or substrate-like targets)** for ubiquitination and downstream consequences including proteasomal degradation or altered solubility/aggregation."
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FBXO33 modulates ubiquitination and solubility of expanded-polyglutamine ataxin-3, reducing toxic aggregation in a proteasome-dependent manner, supporting a protein-quality-control/proteostasis role; it localizes to both nucleus and cytoplasm.
"FBXO33's role in a **CUL1-based ubiquitination pathway** contributing to proteostasis by promoting ubiquitination and reducing toxic aggregation/insolubility of expanded polyQ proteins."
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FBXO33 interacts with YBX1 and contributes to its ubiquitin-dependent degradation, an axis relevant to bone-marrow stromal cell fate during aging.
"FBXO33 interacts with YBX1 and is implicated in **ubiquitin-dependent degradation of YBX1**, with downstream relevance to bone marrow stromal cell (BMSC) aging"
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As a substrate adaptor FBXO33 can be tumor-suppressive (MYC degradation in NSCLC) or oncogenic (p53 destabilization in gallbladder cancer) depending on the dominant substrate context.
"FBXO33 may be context-dependent—potentially **tumor suppressive** via MYC degradation in NSCLC (2024) but **oncogenic** via p53 destabilization in gallbladder cancer (2025)."