Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

UniProt:O15034

UniProtKB entry for RIMS-binding protein 2 (Human)

RIMBP2 localizes to cell membrane and synapse, specifically synaptic plasma membrane

DOI:10.1073/pnas.1605256113

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

RIMBP2 fine-tunes voltage-gated calcium channel positioning at hippocampal synapses
Loss of RIMBP2 modestly reduces release probability and loosens calcium coupling
RIMBP2 localizes to presynaptic active zone nanoclusters

DOI:10.7554/eLife.43243

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

RIMBP2 is critical for Munc13-1 recruitment and stabilization at mossy fiber synapses
RIMBP2 knockout causes severe transmission deficits at mossy fiber synapses
RIMBP2 promotes vesicle docking and priming

DOI:10.1016/j.celrep.2020.107960

A trio of active zone proteins comprised of RIM-BPs, RIMs, and Munc13s governs neurotransmitter release

RIM-RIMBP-Munc13 form a functional triad governing vesicle priming and channel coupling
RIMBP2 can bias synapses toward priming or channel coupling depending on context

file:human/RIMBP2/RIMBP2-deep-research-falcon.md

Deep research review of RIMBP2 function

RIMBP2 is a presynaptic active zone scaffold that coordinates vesicle priming and calcium channel positioning

PMID:27671655

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

RIMBP2 is part of the active-zone scaffold.

"Together, these results indicate that RIM-BP2 is part of the presynaptic AZ scaffold and forms a complex with the priming factors RIM and Munc13-1."

PMID:31535974

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.

RIMBP2 stabilizes Munc13-1 and promotes vesicle docking/priming in mouse mossy-fiber synapses.

"at hippocampal mossy fiber synapses, RIM-BP2 has a substantial impact on neurotransmitter release by promoting vesicle docking/priming and vesicular release probability via stabilization of Munc13-1 at the active zone."

PMID:32755572

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

file:human/RIMBP2/RIMBP2-hypotheses/function-hypothesis-go-0007274/openscientist.md

AIGR Gene Hypothesis Deep Research — RIMBP2 and Neuromuscular Synaptic Transmission (GO:0007274)

The investigation distinguishes an untested vertebrate neuromuscular role from an experimentally refuted role.

"a vertebrate NMJ role remains formally untested rather than disproven"

PMID:22174254

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.

Drosophila RIM-binding protein organizes the active-zone scaffold and neurotransmitter-release machinery.

"Our data identify RBP family proteins as prime effectors of the AZ scaffold"

PMID:26402606

RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release.

Mammalian RIM-BP studies directly test hippocampal and calyx-of-Held synapses.

"we generated double conditional knockout mice for RIM-BP1 and RIM-BP2, and analyzed RIM-BP-deficient synapses in cultured hippocampal neurons and the calyx of Held."