Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.
UniProtKB entry Q12772 (SRBP2_HUMAN), Sterol regulatory element-binding protein 2
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
S1P hydrolyzes SREBP1A,1C,2
S2P hydrolyzes SREBP1A,1C,2
SREBP2:SCAP Transits to the Golgi
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein.
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
Annotation inferences using phylogenetic trees
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
A gut-derived hormone regulates cholesterol metabolism.
Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome.
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.
Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
A human MAP kinase interactome.
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A multi-scale map of cell structure fusing protein images and interactions.
Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.
Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway.
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Combined Automated Annotation using Multiple IEA Methods
Gene Ontology annotation based on curation of immunofluorescence data
SREBP1A,1C,2 translocates to the nucleus
SREBP1A,1C,2:Importin beta-1 dissociates
SREBP1A,1C,2 binds the TM7SF2 promoter
SREBP1A,2 binds the MVD promoter
SREBP1A,1C,2 binds the FDFT1 promoter
SREBP1A,1C,2 binds the FDPS promoter
SREBP1A,1C,2 binds the HMGCS1 promoter
SREBP1A,2 binds the SQLE promoter
SREBP1A,2 binds the IDI1 promoter
SREBP1A,2 binds the LSS promoter
SREBP1A,2 binds the DHCR7 promoter
SREBP1A,2 binds the PMVK promoter
SREBP1A,2 binds the MVK promoter
SREBP1A,2 binds the GGPS1 promoter
SREBP1A,2 binds the HMGCR promoter
SREBP1A,2 binds the CYP51A1 promoter
SREBP1A,2 binds the SC5DL promoter
EGR2 and SREBF2 dimer bind SCD5 gene
EGR2 and SREBF2 dimer bind CYP51A1 gene
EGR2 and SREBF2(1-484) dimer bind HMGCR gene
SREBP2:SCAP Binds CopII Coat Complex
SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG
SREBP2 (SREBF2) is retained in the endoplasmic reticulum by SCAP:INSIG2:oxysterol
Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi.
SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers
SREBP1A,1C,2 binds Importin beta-1
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway.
Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells.
Electronic Gene Ontology annotations created by ARBA machine learning models
Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis.
Gene Ontology annotation through association of InterPro records with GO terms
Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.