Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

EMRE is an essential component of the mitochondrial calcium uniporter complex.

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.

MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.

The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.

Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake.

Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation.

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.

High-affinity cooperative Ca(2+) binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca(2+) Flux and Sensitivity to Ru360.

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex.

Dimerization of MICU Proteins Controls Ca(2+) Influx through the Mitochondrial Ca(2+) Uniporter.

The crystal structure of MICU2 provides insight into Ca(2+) binding and MICU1-MICU2 heterodimer formation.

MICU1 controls cristae junction and spatially anchors mitochondrial Ca(2+) uniporter complex.

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.

Molecular Tuning of the Axonal Mitochondrial Ca(2+) Uniporter Ensures Metabolic Flexibility of Neurotransmission.

Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift.

Structure and mechanism of the mitochondrial Ca(2+) uniporter holocomplex.

Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2.

Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter.

The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.

Structure of intact human MCU supercomplex with the auxiliary MICU subunits.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.

Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex.

MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca(2+) uniporter channel.

MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions.

Multimodal cell maps as a foundation for structural and functional genomics.

Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.

MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix

SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex

MICU proteins facilitate calcium-dependent mitochondrial metabolon formation to regulate cellular energetics independently of MCU.

Asymmetric distribution of mitochondrial Ca(2+) regulators specifies compartment-specific mitochondrial function and neuronal development.