Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids.
Activity of human Delta5 and Delta6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids.
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Yeast coexpression generated C24 PUFA substrates for desaturase assays; the accessible abstract does not identify every elongase construct.
"elongations, produced 24:4n-6 and 24:5n-3, respectively"
Identification and expression of mammalian long-chain PUFA elongation enzymes.
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Human ELOVL2 expressed in yeast elongated both 20- and 22-carbon PUFA (20:4n-6->22:4n-6, 22:4n-6->24:4n-6, 20:5n-3->22:5n-3, 22:5n-3->24:5n-3), identifying ELOVL2 as a very-long-chain PUFA-specific elongase in the Sprecher pathway for DHA synthesis.
"the conversion of 20:4n-6 to 22:4n-6, 22:4n-6 to 24:4n-6, 20:5n-3 to 22:5n-3,"
Development of a high-density assay for long-chain fatty acyl-CoA elongases.
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In comprehensive substrate profiling, ELOVL2 (and ELOVL5) preferentially elongated polyunsaturated fatty acyl-CoAs, whereas ELOVL1/3/6 preferred saturated substrates.
"preferentially elongated the polyunsaturated fatty acyl-CoAs"
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
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The full study assays all seven human ELOVLs, localizes them to ER and reports CERS2 association with each. Individual substrate profiles and functional coupling must be distinguished.
"mammals have seven elongases (ELOVL1-7)"
A reference map of the human binary protein interactome.
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Systematic human binary interactome (HuRI) reporting ELOVL2 Y2H interactions with FXYD6, IFITM3, MALL and TMEM218; no established functional consequence.
"reference interactome map of human binary protein interactions, or 'HuRI'."
The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation.
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Structural/biochemical study of the VLCFA elongation machinery (ELOVL, KAR, HACD, TECR); supports the UniProt-recorded ELOVL2-TECR interaction.
"the VLCFAs elongation machinery is located in ER membrane"
Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA
Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism
ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA
Synthesis of very long-chain fatty acyl-CoAs
ELOVL2: primary evidence scope checked 2026-09-20
ELOVL2 PAINT lineage, GO definitions and IntAct source checks
Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice.