SUN1 review notes

2026-09-27 (claude-code)

Sources: UniProt O94901, cached GOA-cited publications, PMID:19874786, PMID:17724119, SUN1-deep-research-falcon.md.

• Type II INM protein PMID:17724119.
• Binds KASH of nesprins 1-3 PMID:18396275.
• SUN1-KASH1/4/5 6:6 structures PMID:33393904; SUN1-KASH6 9:6 PMID:38291267.
• Nucleokinesis/INM, redundant with SUN2 PMID:19874786.
• NPC distribution PMID:17724119.
• Deep research (Falcon) agrees: core = LINC INM anchor; also NPC/mRNA export (NXF1), meiotic telomere tethering via KASH5, laminopathy modifier. Used as retrieval support only.

Term notes
- GO:0034993 (meiotic LINC) is_a GO:0106094 (verified QuickGO). Rows from somatic SUN-KASH papers were MODIFIED to GO:0106094;
IBA/ARBA and the SUN1-KASH5 structure row kept at GO:0034993 because SUN1 has a genuine meiotic role.
- PMID:22632968 and PMID:33058875 are SUN2 structural papers (full text); SUN1 not directly assayed.
- No KASH-domain-binding MF term exists; SUN-KASH protein binding rows modified to GO:0140444.