Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins.
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.
Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry.
Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.
SOAR and the polybasic STIM1 domains gate and regulate Orai channels.
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.
An EB1-binding motif acts as a microtubule tip localization signal.
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.
Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.
A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.
Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions.
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.
Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis.
Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57.
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.
Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling.
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).
Constitutive activation of the calcium sensor STIM1 causes tubular-aggregate myopathy.
STIM1 and SLC24A4 Are Critical for Enamel Maturation.
Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer.
Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry.
Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1.
A protease-independent function for SPPL3 in NFAT activation.
TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx.
MicroRNA-185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1.
Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation.
Mitochondria control store-operated Ca(2+) entry through Na(+) and redox signals.
Architecture of the human interactome defines protein communities and disease networks.
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction.
Molecular understanding of calcium permeation through the open Orai channel.
A reference map of the human binary protein interactome.
The native ORAI channel trio underlies the diversity of Ca(2+) signaling events.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Physical and functional interactome atlas of human receptor tyrosine kinases.
A central chaperone-like role for 14-3-3 proteins in human cells.
The solute carrier superfamily interactome.
STIM1 binds TRPC1 forming STIM1:TRPC1 complex
TRPC1 translocates calcium from the extracellular region to the cytosol
UniProt record Q13586 (STIM1_HUMAN)