Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Impaired complex I assembly in a Leigh syndrome patient with a novel missense mutation in the ND6 gene.
Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2).
Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia.
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
ND4, ND5 bind the 550kDa complex to form the 815kDa complex
COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.
The coupling mechanism of mammalian respiratory complex I.
From the 'black box' to 'domino effect' mechanism: what have we learned from the structures of respiratory complex I.
Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.