Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
The PI3K p110delta controls T-cell development, differentiation and regulation.
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.
Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function.
Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.
p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors.
The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion.
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Selective p110δ depletion reduces FAK and CDC42 protein expression as well as glioma-cell migration.
"Mechanistically, p110δ knockdown reduced the protein levels of focal adhesion kinase and cell division cycle 42, key regulators of cellular migration."
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.
Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
PI3Kδ and primary immunodeficiencies.
Architecture of the human interactome defines protein communities and disease networks.
Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome.
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis.
A reference map of the human binary protein interactome.
PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
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The p110δ enzyme has broad lipid substrate specificity and intrinsic autophosphorylation, despite not phosphorylating p85.
"p110delta displays a broad phosphoinositide lipid substrate specificity and interacts with SH2/SH3 domain-containing p85 adaptor proteins and with GTP-bound Ras."
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
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Recombinant p110δ phosphorylates PI and associates with p85; the chemistry is distinct from a generic PI3K label.
"Recombinant p110delta phosphorylates phosphatidylinositol and coimmunoprecipitates with p85."
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
CD28 bound PI3K phosphorylates PIP2 to PIP3
Gab2 binds the p85 subunit of Class 1A PI3 kinases
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
EPOR-associated PI3K phosphorylates PIP2 to PIP3
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
14-3-3 zeta binding allows recruitment of PI3K
p-CD19:VAV binds PI3K and GRB2
Falcon deep research report on PIK3CD
UniProtKB record for PIK3CD
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.
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Ser1039 autophosphorylation inhibits lipid kinase activity in vitro; receptor-associated phosphorylation in cells is consistent with, but not exclusive proof of, self-catalysis.
"The single site of autophosphorylation was mapped to Ser1039 at the C-terminus of p110delta."