The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.
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Mosaic analysis revealed that ced-7 functions in both dying cells and engulfing cells during the engulfment process
"Mosaic analysis revealed that ced-7 functions in both dying cells and engulfing cells during the engulfment process"
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the CED-7 protein has sequence similarity to ABC transporters, is broadly expressed during embryogenesis, and is localized to the plasma membrane
"the CED-7 protein has sequence similarity to ABC transporters, is broadly expressed during embryogenesis, and is localized to the plasma membrane"
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Like CED-7, the mammalian ABC transporter ABC1 has been implicated in the engulfment of cell corpses
"Like CED-7, the mammalian ABC transporter ABC1 has been implicated in the engulfment of cell corpses"
CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.
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CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7
"CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7"
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We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses
"We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses"
CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells.
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CED-7 and TTR-52 may promote the efflux of PS from apoptotic cells through the generation of extracellular PS vesicles
"CED-7 and TTR-52 may promote the efflux of PS from apoptotic cells through the generation of extracellular PS vesicles"
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indicating that CED-7 and TTR-52 promote the generation of extracellular PS vesicles
"indicating that CED-7 and TTR-52 promote the generation of extracellular PS vesicles"
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Phagocytic cells also express exPS, which is dependent on the activity of CED-7, TTR-52, and TTR-52-interacting phagocyte receptor CED-1
"Phagocytic cells also express exPS, which is dependent on the activity of CED-7, TTR-52, and TTR-52-interacting phagocyte receptor CED-1"
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
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CED-1, CED-6 and CED-7 are required for actin reorganization around the apoptotic cell corpse
"CED-1, CED-6 and CED-7 are required for actin reorganization around the apoptotic cell corpse"
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
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ced-1, ced-7, or ced-6 single mutants showed a weaker engulfment defect
"ced-1, ced-7, or ced-6 single mutants showed a weaker engulfment defect"
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we found that the CED-1/6/7 pathway appears to play at most a minor role, if any, in this process
"we found that the CED-1/6/7 pathway appears to play at most a minor role, if any, in this process"
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we did observe spindle defects in a small fraction of ced-1; ced-5 double mutants
"we did observe spindle defects in a small fraction of ced-1; ced-5 double mutants"
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
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we used mutations (e.g., ced-1(e1735), ced-6(n2095) or ced-7(n1996)) that cause defects in cell-corpse engulfment and result in the persistence of many embryonic cell corpses into larval stages
"we used mutations (e.g., ced-1(e1735), ced-6(n2095) or ced-7(n1996)) that cause defects in cell-corpse engulfment and result in the persistence of many embryonic cell corpses into larval stages"
Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.
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only mildly enhanced the corpse engulfment defect of the ced-1, ced-6, ced-7 or ttr-52 mutants at the L1 larval stage
"only mildly enhanced the corpse engulfment defect of the ced-1, ced-6, ced-7 or ttr-52 mutants at the L1 larval stage"
Phagocytosis promotes programmed cell death in C. elegans.
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mutations in engulfment genes enhance the frequency of this cell survival
"mutations in engulfment genes enhance the frequency of this cell survival"
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requires the genes ced-1, ced-2, ced-5, ced-6, ced-7, ced-10 and ced-12
"requires the genes ced-1, ced-2, ced-5, ced-6, ced-7, ced-10 and ced-12"
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans.
Cooperation between engulfment receptors: the case of ABCA1 and MEGF10.
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MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7
"MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7"
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods