Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
LDL receptor-related protein as a component of the midkine receptor.
Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages.
Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid.
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.
Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1.
Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.
Integral and associated lysosomal membrane proteins.
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.
Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides.
Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.
CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Phosphorylation of LRP1 regulates the interaction with Fe65.
Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier.
Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1.
Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.
Neuronal clearance of amyloid-β by endocytic receptor LRP1.
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans.
Establishment and Dysfunction of the Blood-Brain Barrier.
Clearance of matrix metalloproteinase-9 is dependent on low-density lipoprotein receptor-related protein-1 expression downregulated by microRNA-205 in human abdominal aortic aneurysm.
The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein.
Architecture of the human interactome defines protein communities and disease networks.
Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.
Blood-Brain Barrier: From Physiology to Disease and Back.
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation.
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response.
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multiple LDLR family members act as entry receptors for yellow fever virus.
Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2.
LRP1 (CD91) binds Hemopexin:heme
LRP1:Hemopexin:heme is endocytosed
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol
Retinoid metabolism and transport
UniProt text export for LRP1 (Q07954)