Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.
MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Expression of SERP1 (RAMP4)
SGTA binds Tail-anchored protein
UniProt entry Q9Y6X1 (SERP1_HUMAN), stress-associated endoplasmic reticulum protein 1 / RAMP4
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Single-pass ER membrane protein that interacts with target proteins during ER translocation, protects unfolded targets against degradation during ER stress, and facilitates their glycosylation after stress; interacts with the SEC61 complex and calnexin.
Structural analysis of the dynamic ribosome-translocon complex.
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Cryo-EM of native ribosome-translocon complexes shows that a large proportion contain RAMP4 (SERP1) intercalated into the Sec61 lateral gate, widening the central pore and contributing to its hydrophilic interior; this places SERP1/RAMP4 as a structural, gating-modulating component of the Sec61 translocon.
A Dengue Virus Type 2 (DENV-2) NS4B-Interacting Host Factor, SERP1, Reduces DENV-2 Production by Suppressing Viral RNA Replication.
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SERP1 was identified as a DENV-2 NS4B-interacting host factor; SERP1 is strongly induced (~34.5-fold) under DENV-2-induced ER stress, and SERP1 overexpression suppresses DENV-2 RNA replication and viral yield, consistent with a protective ER-stress-associated role.
SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3beta/beta-catenin/TCF/LEF signaling pathway.
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In acute hepatic injury models, SERP1 expression rises with ER stress, and SERP1 overexpression reduces ER-stress markers (GRP78/GRP94/CHOP), apoptosis, and inflammation, supporting a cytoprotective role during ER stress.
A clearer picture of the ER translocon complex.