BICD2 review notes

2026-09-27 (claude-code)

• Identity: human BICD2 (Q8TD16), BicD family coiled-coil dynein cargo adaptor.
• Activating adaptor: PMID:24986880; PMID:25814576.
• Golgi/RAB6 route: PMID:25962623.
• Nuclear pore route (G2): PMID:20386726; activation by CDK1/PLK1 PMID:37105961; INM in rat RGPs PMID:24034252.
• LINC route (neurons): [PMID:32619477 "the motor proteins interact with Nesprin-2 through the dynein/kinesin \"adaptor\" BicD2, both in neurons and in non-mitotic fibroblasts"].
• Decisions: protein binding RanBP2 -> MODIFY GO:0008093; dynein IC/RAB6A -> MODIFY GO:0070840 + GO:0031267; Hem-1 proteomics and KIF1C (abstract lacks it) -> REMOVE. Nuclear pore part_of and annulate lamellae kept non-core (transient G2 recruitment, peripheral). GSK-3beta/BICD (PMID:17139249, abstract emphasizes BICD1) microtubule anchoring/regulation rows kept non-core, not removed.
• NEW: GO:0007097 nuclear migration (comparators HOOK3 GO:0022027, DYNC1H1/PAFAH1B1/SYNE2 GO:0007097 in human GOA); GO:0140660 cytoskeletal motor activator activity (PMID:24986880, verified via PubMed eutils).
• Deep research (falcon) consulted: consistent (activating adaptor; RAB6, RANBP2, nesprin-2 cargos; CDK1-PLK1 activation; SMALED2).
• Local oaklib GO cache labels GO:0008093 as "cytoskeletal anchor activity"; OLS/QuickGO current label is "cytoskeletal adaptor activity" (validator warning only).
• Module check: GO:0008093 at nuclear envelope for both routes agrees; consider adding GO:0140660 as a secondary function of the BICD2 annotons.