Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
Mediation of the DCC apoptotic signal by DIP13 alpha.
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
Towards a proteome-scale map of the human protein-protein interaction network.
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.
Crystal structures of the BAR-PH and PTB domains of human APPL1.
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.
Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.
The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.
An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons.
Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes.
Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
The functional interactome landscape of the human histone deacetylase family.
The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
Phospho-tyrosine dependent protein-protein interaction network.
Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus.
APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.
Architecture of the human interactome defines protein communities and disease networks.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Quantitative fragmentomics allow affinity mapping of interactomes.
Multimodal cell maps as a foundation for structural and functional genomics.
Caspase-9 binds DCC:DIP13alpha complex
DCC interacts with DIP13alpha