Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
"ATAD3C regulates ATAD3A assembly and function in the mitochondrial membrane".
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ATAD3C is an expressed integral membrane protein with its C-terminus in the IMS.
"We detected unique ATAD3C peptides in HEK 293T cells, with expression similar to that in human tissues, and showed that it is an integral membrane protein that exposes its carboxy-terminus to the intermembrane space."
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ATAD3C incorporates into and shrinks ATAD3A complexes.
"This was due to the incorporation of ATAD3C monomers in ATAD3A complex in the mitochondrial membrane reducing its size."
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ATAD3C acts as a dominant-negative regulator of ATAD3A.
"Our results demonstrate a negative dominant role of the ATAD3C paralog with implications for mitochondrial OXPHOS function and suggest that its expression regulates ATAD3A in the cell."
Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism.
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The ATAD3A-C fusion replaces the ATAD3A arginine finger R466 with cysteine from ATAD3C.
"(C) The ATAD3A arginine finger, Arg466 (yellow) which is changed to a cysteine in the ATAD3A-C fusion gene, is overlaid with the SPAST arginine finger (Arg499; orange)."
ATAD3C AAA+ catalytic-residue check
UniProt entry Q5T2N8 (ATD3C_HUMAN)
Affinage mechanistic annotation for ATAD3C (human)